Oncogenes Meet Metabolism
From Deregulated Genes to a Broader Understanding of Tumour Physiology
Nonfiction, Health & Well Being, Medical, Medical Science, Physiology, Specialties, Oncology
| Author: | ISBN: | 9783540794783 | |
| Publisher: | Springer Berlin Heidelberg | Publication: | July 25, 2008 |
| Imprint: | Springer | Language: | English |
| Author: | |
| ISBN: | 9783540794783 |
| Publisher: | Springer Berlin Heidelberg |
| Publication: | July 25, 2008 |
| Imprint: | Springer |
| Language: | English |
In 1920s, Otto Warburg described the phenomenon of ‘aerobic glycolysis’, the ability of tumour cells to convert glucose to lactate in the presence of normal oxygen conditions. Warburg’s hypothesis of an altered metabolism in cancer cells found no immediate acceptance, though it was latter confirmed for most human tumours. With the advent of molecular biology the focus in tumour research has shifted towards the search for oncogenes. However, the interest in cancer molecular profiling eventually led to a renaissance of the Warburg effect trying to combine genetic alterations with effects on metabolism with the help of modern analytic technologies to rapidly analyze broad varieties of metabolites in various tissues and bodyfluids (metabonomics).
In 1920s, Otto Warburg described the phenomenon of ‘aerobic glycolysis’, the ability of tumour cells to convert glucose to lactate in the presence of normal oxygen conditions. Warburg’s hypothesis of an altered metabolism in cancer cells found no immediate acceptance, though it was latter confirmed for most human tumours. With the advent of molecular biology the focus in tumour research has shifted towards the search for oncogenes. However, the interest in cancer molecular profiling eventually led to a renaissance of the Warburg effect trying to combine genetic alterations with effects on metabolism with the help of modern analytic technologies to rapidly analyze broad varieties of metabolites in various tissues and bodyfluids (metabonomics).
